At the follow-up visit (day 28-32), 90.8% of patients treated with amoxicillin and 92.6% of those treated with penicillin V were free of GABHS (p = 0.85). 1996 Aug;15(8):678-82. doi: 10.1097/00006454-199608000-00008.Carbon C, Chatelin A, Bingen E, Zuck P, Rio Y, Guetat F, Orvain J.J Antimicrob Chemother. 2017 Dec;49(4):326-352. doi: 10.3947/ic.2017.49.4.326.Omurzakova NA, Yamano Y, Saatova GM, Alybaeva MS, Nishioka K, Nakajima T.Open Rheumatol J. The steering committee agreed definitions of outcome measures to guide the outcome adjudicators before unblinding the two study groups. In the 10 day group the corresponding figures were 83.7% (159/190) with a median duration of 3.0 days (1.0–5.0 days).We found that penicillin V four times daily for five days was non-inferior in clinical outcome to penicillin V three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci.

Bei mangelndem Behandlungserfolg handelt es sich eher um Reinfektionen, wenn eben das Kind in Kindergarten, Schule oder Hort sich bei anderen Kindern wieder ansteckt. Irrespective of allocated treatment regimen, 63% (54/86) of the patients would prefer to take penicillin V four times a day for five days, and 22% (19/86) would prefer to take the drug three times a day for 10 days. Inclusion criteria were patients aged 6 years and over with three or four Centor criteria (fever >38.5°C, tender lymph nodes, coatings of the tonsils (for children inflamed tonsils), and absence of cough), and a positive rapid antigen detection test for group A streptococcus. Tolerability was good in both groups.

Sore throat (acute): antimicrobial prescribing 2018. for 6 days and penicillin V 1 MU t.i.d. = Kalium-Ion (99 mg pro 1 Tablette) Curtin-Wirt C, Casey JR, Murray PC, Cleary CT, Hoeger WJ, Marsocci SM, Murphy ML, Francis AB, Pichichero ME.Clin Pediatr (Phila).

Guideline on the choice of the non-inferiority margin, EMEA/CPMP/EWP/2158/99.

When patients had complications, we collected details retrospectively from their medical records. A randomized trial of seven vs ten days’ therapyFive versus ten days treatment of group A streptococcal pharyngotonsillitis: a randomized controlled clinical trial with phenoxymethylpenicillin and cefadroxilPenicillin for acute sore throat: randomised double blind trial of seven days versus three days treatment or placebo in adultsA randomized controlled study of 5 and 10 days treatment with phenoxymethylpenicillin for pharyngotonsillitis caused by streptococcus group A - a protocol studyPenicillin for acute sore throat in children: randomised, double blind trialThe path of least resistance: aggressive or moderate treatment?Low dosage and long treatment duration of beta-lactam: risk factors for carriage of penicillin-resistant Streptococcus pneumoniaeReduction of antibiotic use in the community reduces the rate of colonization with penicillin G-nonsusceptible Streptococcus pneumoniaeReattendance and complications in a randomised trial of prescribing strategies for sore throat: the medicalising effect of prescribing antibioticsPenicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study Of the 433 randomised patients, 422 represented the modified intention to treat population and 397 represented the per protocol population.